Dr. Wassim Elyaman
Assistant Professor of Neurological Sciences
Dr. Bradshaw began her work in human immunology in the Ann Romney Center for Neurologic Diseases at Brigham and Women’s Hospital and Harvard Medical School as a Research Fellow in clinical immunology. In 2014, she was promoted to the rank of Assistant Professor. In 2017 she moved to Columbia and joined the newly formed Center for Translation and Computational Neuroimmunology in the Department of Neurology.
A main focus of Dr. Bradshaw’s work has been understanding the role of the human innate immune system, both central and peripheral, in complex neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease. Interestingly, genetic studies of Alzheimer’s disease directly implicate the involvement of the innate immune system. In Parkinson’s disease, the genetic modulation of the immune system is still being uncovered. Currently, one of Dr. Bradshaw’s major research interests is the translation of findings from these studies, to molecular outcomes and potentially therapeutically targetable molecules in innate immune cells.
Dr. Elyaman trained in neuroimmunology in the Ann Romney Center for Neurologic Diseases at Brigham and Women’s Hospital and Harvard Medical School. Dr. Elyaman's research is aimed to understand how regions of the human genome containing risk alleles alter the function of adaptive and innate immune cells and, in doing so, increases an individual’s risk of developing neurodegenerative diseases.
Another line of research in Dr. Elyaman’s lab is to understand the role of adaptive immune cells in aging and neurological diseases including Alzheimer’s disease, Parkinson's disease and epilepsy and how circulating immune cells interact with CNS resident innate cells. To this end, both human and murine systems are leveraged to dissect the molecular mechanisms of this interaction and its influence on the disease initiation and progression.
Dr. Victoria Leavitt
Assistant Professor of Neuropsychology